Can i take lansoprazole with levothyroxine

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Looking for answers on taking lansoprazole with levothyroxine? If you’re considering using these medications together, it’s important to understand the potential risks and benefits. While lansoprazole is a proton pump inhibitor that helps reduce stomach acid production, levothyroxine is a synthetic thyroid hormone used to treat hypothyroidism. Consult with your healthcare provider to ensure safe and effective use of these medications together.

Interaction Mechanism

When lansoprazole and levothyroxine are taken together, there is a potential for drug-drug interactions. Lansoprazole may decrease the absorption of levothyroxine in the stomach, leading to reduced effectiveness of levothyroxine. This is mainly due to the increased gastric pH caused by lansoprazole, which can interfere with the absorption of levothyroxine, a thyroid hormone replacement medication. As a result, it is recommended to take these medications at least 4 hours apart to minimize the risk of interaction.

Interaction Mechanism

When Lansoprazole and Levothyroxine are taken together, there is a potential for drug-drug interactions. Lansoprazole can reduce the absorption of Levothyroxine in the gastrointestinal tract, leading to decreased effectiveness of Levothyroxine. This interaction occurs due to Lansoprazole’s ability to increase stomach pH, which can interfere with the absorption of Levothyroxine.

It is recommended to take Levothyroxine on an empty stomach at least 30 minutes before eating to ensure proper absorption. If you are taking Lansoprazole, it is important to discuss with your healthcare provider about the timing of your medications to avoid any potential interactions.

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Recommendation Explanation
Take Levothyroxine on an empty stomach Helps ensure proper absorption
Avoid taking Lansoprazole with Levothyroxine To prevent decreased effectiveness of Levothyroxine
Consult healthcare provider To discuss timing of medications and potential interactions

Side Effects

It is important to be aware of the potential side effects of taking lansoprazole with levothyroxine. Some common side effects may include:

1. Gastrointestinal Issues

1. Gastrointestinal Issues

Some individuals may experience digestive problems such as nausea, stomach pain, or diarrhea when taking these medications together.

2. Changes in Thyroid Function

There is a possibility that combining lansoprazole with levothyroxine may affect thyroid function and require monitoring by a healthcare provider.

It is crucial to consult with a healthcare professional before starting these medications together to discuss any potential side effects and ways to manage them.


Before taking lansoprazole with levothyroxine, it is important to consider the following precautions:

  1. Inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal supplements.
  2. Discuss any known allergies to lansoprazole or levothyroxine with your doctor.
  3. Follow the recommended dosage and schedule provided by your healthcare provider.
  4. Avoid taking these medications with certain foods or substances that may interact with them.
  5. Do not stop or change the dosage of lansoprazole or levothyroxine without consulting your healthcare provider.
  6. Keep lansoprazole and levothyroxine out of reach of children and store them in a cool, dry place.