Is levothyroxine and synthroid the same

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Understanding Levothyroxine and Synthroid

Levothyroxine and Synthroid are both medications used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. They both contain the same active ingredient, which is synthetic thyroxine (T4). However, there are some differences between the two medications.

Levothyroxine is a generic medication, while Synthroid is a brand-name medication. This means that Synthroid may be more expensive than levothyroxine, but both medications are equally effective in treating hypothyroidism.

Some patients may prefer brand-name Synthroid over generic levothyroxine due to perceived differences in quality or consistency. However, both medications are regulated by the FDA and must meet the same safety and quality standards.

It is important to follow your healthcare provider’s recommendations when choosing between levothyroxine and Synthroid. Your healthcare provider will consider factors such as cost, insurance coverage, and personal preference when prescribing medication for hypothyroidism.

Main Differences Between Them

When comparing levothyroxine and Synthroid, it’s important to understand that they are essentially the same medication. Levothyroxine is the generic version, while Synthroid is a brand-name version. The active ingredient in both is levothyroxine sodium.

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However, some patients may experience differences in effectiveness and side effects when switching between the two. The main variations may come from the inactive ingredients used in the manufacturing of each medication. This can affect how the body absorbs and utilizes the drug, potentially leading to different outcomes for patients.


In most cases, both levothyroxine and Synthroid are equally effective at treating hypothyroidism. However, some patients may find that they respond better to one brand over the other. It’s essential to work with your healthcare provider to find the right medication for your specific needs.

Side Effects:

The potential side effects of levothyroxine and Synthroid are similar since they contain the same active ingredient. Common side effects may include hair loss, weight changes, insomnia, and heart palpitations. It’s crucial to monitor and report any side effects to your doctor.

Effectiveness and Side Effects Compared

Levothyroxine and Synthroid are both effective medications for treating hypothyroidism. Both drugs work by replacing the hormone that your thyroid gland is unable to produce. They are often prescribed to help regulate your body’s metabolism and energy levels.


Studies have shown that both levothyroxine and Synthroid are equally effective in treating hypothyroidism. They are both synthetic forms of the thyroid hormone thyroxine (T4) and work in the same way once they are absorbed into your body.

Side Effects

While levothyroxine and Synthroid are generally well-tolerated, they can cause side effects in some people. Common side effects may include headache, nervousness, tremors, rapid heartbeat, or weight loss. It’s important to talk to your doctor if you experience any side effects while taking either medication.

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Interactions with Other Drugs

Levothyroxine and Synthroid may interact with several other drugs, potentially leading to adverse effects or reduced effectiveness. It is crucial to inform your healthcare provider about all medications, supplements, and herbs you are taking before starting treatment with levothyroxine or Synthroid.

Common Drug Interactions:

1. Antacids: Antacids containing aluminum or magnesium may decrease the absorption of levothyroxine or Synthroid. It is recommended to take these medications at least 4 hours apart.

2. Calcium Supplements: Calcium supplements, as well as calcium-rich foods, can also interfere with the absorption of levothyroxine and Synthroid. It is advisable to separate the intake of these medications by at least 4 hours.

3. Iron Supplements: Iron supplements may reduce the effectiveness of levothyroxine or Synthroid. It is advisable to take these medications at least 2 hours apart.

Less Common Interactions:

1. Antidepressants: Some antidepressants, such as tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs), may interact with levothyroxine and Synthroid, altering their levels in the body.

2. Blood Thinners: Anticoagulant medications like warfarin may require dosage adjustments when taken concomitantly with levothyroxine or Synthroid, as they can affect blood clotting mechanisms.

3. Diabetes Medications: Insulin or oral diabetes medications may need to be adjusted when taken with levothyroxine or Synthroid, as these drugs can influence blood sugar levels.

It is essential to consult your healthcare provider if you experience any unusual symptoms or side effects while taking levothyroxine or Synthroid in combination with other drugs. Do not modify your medication regimen without medical supervision.

Interactions with Other Drugs

It is crucial to be aware of potential interactions between levothyroxine and other drugs, as these interactions can affect the effectiveness of the medication or lead to adverse effects. Here are some common interactions to be mindful of:

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1. Antacids and Calcium Supplements

  • Antacids containing aluminum or magnesium may reduce the absorption of levothyroxine. It is recommended to take these medications at least four hours apart to avoid interaction.
  • Calcium supplements, especially when taken with iron supplements or certain multivitamins, can also interfere with levothyroxine absorption. Consult your healthcare provider for guidance on timing and dosage.

2. Antidepressants

  • Some antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants, may affect thyroid hormone levels. Close monitoring and dosage adjustments may be necessary when using these medications alongside levothyroxine.

Always inform your healthcare provider about all the medications, supplements, and herbal products you are taking to avoid potential interactions with levothyroxine. Adjustments in dosages or timings may be required to ensure optimal treatment outcomes.

Availability and Cost Comparison

Availability and Cost Comparison

When it comes to availability and cost, both Levothyroxine and Synthroid are widely accessible and commonly prescribed medications for thyroid conditions. They are available in most pharmacies and can be obtained with a prescription from your healthcare provider.


Levothyroxine is available as a generic medication, which means it is usually less expensive compared to the brand-name drug Synthroid. The generic form of levothyroxine is widely available and prescribed by healthcare providers as a cost-effective alternative.

Cost Comparison:

Medication Cost Range
Levothyroxine (Generic) $4 – $20 for a 30-day supply
Synthroid (Brand-name) $30 – $70 for a 30-day supply

As seen in the cost comparison table, the generic form of Levothyroxine is generally more affordable than the brand-name Synthroid. However, the actual cost may vary depending on your insurance coverage, pharmacy discounts, and dosage prescribed by your healthcare provider.